ERCC6L Polyclonal Antibody

Catalog number E-AB-11196-01

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Price for E-AB-11196-01

Size / count 20 µL

Specifications

Catalog number: E-AB-11196-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.
Abbreviation: ERCC6L
UniProt: Q2NKX8
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant protein of human ERCC6L
Target: ATP dependent helicase ERCC6 like; ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC 6 like; DNA excision repair protein ERCC-6-like; ERC6L; ERCC 6L; Ercc6l; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105; MGC131695; PICH; Plk1 interacting checkpoint helicase; PLK1-interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ HCC 15; Tumor antigen BJ-HCC-15
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cell Biology; Epigenetics and Nuclear Signaling
Purification: Affinity purification
Concentration: 0.5 mg/mL
Dilution: IHC 1:50-1:200
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for ERCC6L Polyclonal Antibody?

The catalog number for ERCC6L Polyclonal Antibody is E-AB-11196.

What sizes are available for ERCC6L Polyclonal Antibody?

ERCC6L Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does ERCC6L Polyclonal Antibody come in?

ERCC6L Polyclonal Antibody is available in 4 different pack sizes.

Is ERCC6L Polyclonal Antibody in stock?

ERCC6L Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ERCC6L Polyclonal Antibody?

ERCC6L Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for ERCC6L Polyclonal Antibody?

Estimated delivery time for ERCC6L Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ERCC6L Polyclonal Antibody?

The safety data sheet for ERCC6L Polyclonal Antibody is available here: https://789.bio/eb/zvnLmL.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.