IDH2 Polyclonal Antibody

Specifications

Catalog number

E-AB-11319-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . Five isocitrate dehydrogenases have been reported: three NAD (+) -dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP (+) -dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP (+) -dependent isozyme is a homodimer. The protein encoded by this gene is the NADP (+) -dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Abbreviation

IDH2

UniProt

P48735

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human IDH2

Target

D2HGA2; ICD-M; IDH; IDH2; IDHM; IDHP; IDP; IDPM; Isocitrate dehydrogenase [NADP]; mitochondrial; Isocitrate dehydrogenase 2 (NADP+) ; mitochondrial; mNADP-IDH; NADP (+) -specific ICDH; Oxalosuccinate decarboxylase

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Metabolism; Signal Transduction

Purification

Affinity purification

Concentration

0.3 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

51kDa

Isotype

IgG