RAD50 Polyclonal Antibody

Specifications

Catalog number

E-AB-12632-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Abbreviation

RAD50

UniProt

Q92878

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide of human RAD50

Target

DNA repair protein RAD50; hRAD50; hsRAD50; Mrell; NBSLD; Rad 50; RAD50 2; rad50; RAD50 homolog (S cerevisiae) ; RAD50 homolog; RAD50 PEN; RAD50; S. cerevisiae; homolog of; RAD50; RAD502; Rad50l; Truncated RAD50 protein

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Epigenetics and Nuclear Signaling

Purification

Affinity purification

Concentration

0.4 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

154kDa

Citation 01

https://link.springer.com/content/pdf/10.1007/s12035-020-01884-8.pdf

Isotype

IgG