TOP2A Polyclonal Antibody

Catalog number E-AB-12664-01

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Price for E-AB-12664-01

Size / count 20 µL

Specifications

Catalog number: E-AB-12664-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Abbreviation: TOP2A
UniProt: P11388
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Synthetic peptide of human TOP2A
Target: Alpha isozyme; ATP hydrolyzing DNA topoisomerase II alfa; DNA gyrase; DNA topoisomerase (ATP hydrolyzing) ; DNA topoisomerase 2 alpha; DNA topoisomerase 2-alpha; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA topoisomerase II; DNA Topoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A; Topoisomerase DNA II alpha 170kDa; TP2A
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Epigenetics and Nuclear Signaling
Purification: Affinity purification
Concentration: 0.2 mg/mL
Dilution: IHC 1:50-1:200
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for TOP2A Polyclonal Antibody?

The catalog number for TOP2A Polyclonal Antibody is E-AB-12664.

What sizes are available for TOP2A Polyclonal Antibody?

TOP2A Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does TOP2A Polyclonal Antibody come in?

TOP2A Polyclonal Antibody is available in 4 different pack sizes.

Is TOP2A Polyclonal Antibody in stock?

TOP2A Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TOP2A Polyclonal Antibody?

TOP2A Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for TOP2A Polyclonal Antibody?

Estimated delivery time for TOP2A Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TOP2A Polyclonal Antibody?

The safety data sheet for TOP2A Polyclonal Antibody is available here: https://789.bio/eb/5y1yL0.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.