LCN2 Polyclonal Antibody

Catalog number E-AB-12805-01

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Price for E-AB-12805-01

Size / count 20 µL

Specifications

Catalog number: E-AB-12805-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Abbreviation: LCN2
UniProt: P80188
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide of human LCN2
Target: 24p3;25 kDa alpha 2 microglobulin related subunit of MMP9;25 kDa alpha-2-microglobulin-related subunit of MMP-9; Alpha 2 microglobulin related protein; HGNC:6526; HNL; Lcn 2; Lcn2; Lipocalin-2; Migration stimulating factor inhibitor; MSFI; Neutrophil gelatinase associated lipocalin; Neutrophil gelatinase associated lipocalin precursor; Neutrophil gelatinase-associated lipocalin; NGAL; NGAL; Oncogene 24p3; Oncogenic lipocalin 24p3; p25; Siderocalin; siderocalin LCN2; SV40 induced 24P3 protein; Uterocalin
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Cardiovascular; Metabolism; Immunology; Signal Transduction
Purification: Affinity purification
Concentration: 0.5 mg/mL
Dilution: IHC 1:25-1:100
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for LCN2 Polyclonal Antibody?

The catalog number for LCN2 Polyclonal Antibody is E-AB-12805.

What sizes are available for LCN2 Polyclonal Antibody?

LCN2 Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does LCN2 Polyclonal Antibody come in?

LCN2 Polyclonal Antibody is available in 4 different pack sizes.

Is LCN2 Polyclonal Antibody in stock?

LCN2 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures LCN2 Polyclonal Antibody?

LCN2 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for LCN2 Polyclonal Antibody?

Estimated delivery time for LCN2 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for LCN2 Polyclonal Antibody?

The safety data sheet for LCN2 Polyclonal Antibody is available here: https://789.bio/eb/mv9ub9.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.