FZD6 Polyclonal Antibody

Specifications

Catalog number

E-AB-12926-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Abbreviation

FZD6

UniProt

O60353

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Synthetic peptide of human FZD6

Target

Frizzled 6 seven transmembrane spanning receptor; Frizzled drosophila homolog of 6; Frizzled family receptor 6; Frizzled homolog 6 (Drosophila) ; Frizzled homolog 6; Frizzled-6; Frizzled6; Fz 6; Fz-6; Fz6; FZD 6; Fzd6; FZD6; Hfz 6; hFz6; NDNC10

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Stem Cells

Purification

Affinity purification

Concentration

0.2 mg/mL

Dilution

IHC 1:100-1:300

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG