HMGB1 Polyclonal Antibody

Catalog number E-AB-15716-01

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Price for E-AB-15716-01

Size / count 20 µL

Specifications

Catalog number: E-AB-15716-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
Abbreviation: HMGB1
UniProt: P09429
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Synthetic peptide of human HMGB1
Target: Amphoterin; Chromosomal protein; nonhistone; HMG1; DKFZp686A04236; High mobility group 1; High mobility group box 1; High mobility group protein 1; High mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; HMG-1; HMG1; HMG3; HMGB 1; HMGB1; HMGB1; NONHISTONE CHROMOSOMAL PROTEIN HMG1; SBP 1; Sulfoglucuronyl carbohydrate binding protein
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC
Field of Research: Cancer; Epigenetics and Nuclear Signaling
Purification: Affinity purification
Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000; IHC 1:50-1:200
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 25kDa
Citation 01: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689815/
Isotype: IgG

Frequently Asked Questions

What is the catalog number for HMGB1 Polyclonal Antibody?

The catalog number for HMGB1 Polyclonal Antibody is E-AB-15716.

What sizes are available for HMGB1 Polyclonal Antibody?

HMGB1 Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does HMGB1 Polyclonal Antibody come in?

HMGB1 Polyclonal Antibody is available in 4 different pack sizes.

Is HMGB1 Polyclonal Antibody in stock?

HMGB1 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HMGB1 Polyclonal Antibody?

HMGB1 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for HMGB1 Polyclonal Antibody?

Estimated delivery time for HMGB1 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HMGB1 Polyclonal Antibody?

The safety data sheet for HMGB1 Polyclonal Antibody is available here: https://789.bio/eb/qbPq90.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.