DLAT Polyclonal Antibody

Catalog number E-AB-17216-01

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Price for E-AB-17216-01

Size / count 20 µL

Specifications

Catalog number: E-AB-17216-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC) . PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC) . In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
Abbreviation: DLAT
UniProt: P10515
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Fusion protein of human DLAT
Target: 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Dihydrolipoamide S Acetyltransferase; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial; DLAT; DLTA; E2; E2 component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; mitochondrial; ODP2; PBC; PDC E2; PDC-E2; PDCE2; Pyruvate dehydrogenase complex component E2; Pyruvate dehydrogenase complex E2 subunit
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Metabolism; Signal transduction
Purification: Affinity purification
Concentration: 0.6 mg/mL
Dilution: IHC 1:30-150
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 69 kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for DLAT Polyclonal Antibody?

The catalog number for DLAT Polyclonal Antibody is E-AB-17216.

What sizes are available for DLAT Polyclonal Antibody?

DLAT Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does DLAT Polyclonal Antibody come in?

DLAT Polyclonal Antibody is available in 4 different pack sizes.

Is DLAT Polyclonal Antibody in stock?

DLAT Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DLAT Polyclonal Antibody?

DLAT Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for DLAT Polyclonal Antibody?

Estimated delivery time for DLAT Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DLAT Polyclonal Antibody?

The safety data sheet for DLAT Polyclonal Antibody is available here: https://789.bio/eb/iPKCmD.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.