GAD1 Polyclonal Antibody

Specifications

Catalog number

E-AB-17390-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Abbreviation

GAD1

UniProt

Q99259

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide of human GAD1

Target

67 kDa glutamic acid decarboxylase; CPSQ1; DCE1; DCE1; EC 4.1.1.15; FLJ45882; GAD 67; GAD; GAD-67; GAD1; Glutamate decarboxylase 1 (brain;67kDa) ; Glutamate decarboxylase 1; Glutamate decarboxylase 1 brain 67kD; Glutamate decarboxylase 1 brain 67kDa; Glutamate decarboxylase 67 kDa isoform; Glutamate decarboxylase; brain;67-KD; OTTHUMP00000041055; SCP

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Metabolism; Immunology; Signal transduction

Purification

Affinity purification

Concentration

0.2 mg/mL

Dilution

WB 1:200-1000; IHC 1:25-100

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

67 kDa

Isotype

IgG