HTT Polyclonal Antibody

Catalog number E-AB-18100-01

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Price for E-AB-18100-01

Size / count 20 µL

Specifications

Catalog number: E-AB-18100-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.
Abbreviation: HTT
UniProt: P42858
Host: Rabbit
Reactivity: Human; Rat
Immunogen: Synthetic peptide of human HTT
Target: AI256365; C430023I11Rik; HD; HD protein; HD; HDH; HTT; Huntingtin; HUNTINGTON CHOREA; Huntington disease protein; Huntington's disease protein homolog; IT 15; IT15; OTTMUSP00000026909; ZHD
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Neuroscience
Purification: Antigen affinity purification
Concentration: 0.78 mg/mL
Dilution: IHC 1:40-1:200
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for HTT Polyclonal Antibody?

The catalog number for HTT Polyclonal Antibody is E-AB-18100.

What sizes are available for HTT Polyclonal Antibody?

HTT Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does HTT Polyclonal Antibody come in?

HTT Polyclonal Antibody is available in 4 different pack sizes.

Is HTT Polyclonal Antibody in stock?

HTT Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HTT Polyclonal Antibody?

HTT Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for HTT Polyclonal Antibody?

Estimated delivery time for HTT Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HTT Polyclonal Antibody?

The safety data sheet for HTT Polyclonal Antibody is available here: https://789.bio/eb/e1iznP.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.