KCNN2 Polyclonal Antibody

Specifications

Catalog number

E-AB-18171-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. KCNN2 (Potassium Calcium-Activated Channel Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Serotonergic synapse and Bile secretion. GO annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is KCNN3.

Abbreviation

KCNN2

UniProt

Q9H2S1

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide of human KCNN2

Target

Apamin sensitive small conductance Ca2+ activated potassium; Apamin sensitive small conductance Ca2+ activated potassium channel; hSK2; KCa2.2; Kcnn2; Potassium intermediate/small conductance calcium activated; Potassium intermediate/small conductance calcium activated channel subfamily N member 2; SK2; SKCa 2; SKCa2; Small conductance calcium activated potassium channel; Small conductance calcium activated potassium channel protein 2; Small conductance calcium-activated potassium channel protein 2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Neuroscience

Purification

Antigen affinity purification

Concentration

1.86 mg/mL

Dilution

IHC 1:50-1:300

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG