KCNN3 Polyclonal Antibody

Specifications

Catalog number

E-AB-18172-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

KCNN3 (Potassium Calcium-Activated Channel Subfamily N Member 3) is a Protein Coding gene. Diseases associated with KCNN3 include Spinocerebellar Ataxia 2 and Bipolar Disorder. Among its related pathways are Insulin secretion and Transmission across Chemical Synapses. GO annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Abbreviation

KCNN3

UniProt

Q9UGI6

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide of human KCNN3

Target

HSK3; KCa2.3; Kcnn3; KCNN3; Potassium calcium activated channel subfamily N member 3; Potassium channel calcium activated intermediate/small conductance subfamily N alpha member 3; Potassium channel; calcium activated; intermediate/small conductance; subfamily N; member 3; Potassium intermediate/small conductance calcium activated channel subfamily N member 3; SK3; SKCa 3; SKCa3; Small conductance calcium-activated potassium channel protein 3

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Neuroscience; Signal Transduction

Purification

Antigen affinity purification

Concentration

1.08 mg/mL

Dilution

IHC 1:40-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG