SHTN1 Polyclonal Antibody

Specifications

Catalog number

E-AB-18189-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.

Abbreviation

SHTN1

UniProt

A0MZ66

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide of human SHTN1

Target

DKFZp686A0439; hypothetical protein FLJ11122; Kiaa1598; MGC40476; Putative uncharacterized protein KIAA1598; Shootin 1; Shootin-1; SHOT1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Neuroscience

Purification

Antigen affinity purification

Concentration

0.78 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:100

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

72 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG