RIPK1 Polyclonal Antibody

Catalog number E-AB-18284-01

Choose a variant (4 options)

Selecting a variant updates its price, size and availability.

Price for E-AB-18284-01

Size / count 20 µL

Specifications

Catalog number: E-AB-18284-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Abbreviation: RIPK1
UniProt: Q13546
Host: Rabbit
Reactivity: Human
Immunogen: Fusion protein of human RIPK1
Target: Cell death protein RIP; FLJ39204; OTTHUMP00000039163; Receptor (TNFRSF) interacting serine threonine kinase 1; receptor interacting protein 1; Receptor interacting protein; Receptor interacting protein kinase 1; Receptor interacting serine threonine protein kinase 1; Receptor TNFRSF interacting serine threonine kinase 1; Receptor-interacting protein 1; Receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP 1; RIP; Rip-1; RIP1; RIPK 1; Ripk1; RIPK1; Serine threonine protein kinase RIP; Serine/threonine-protein kinase RIP
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC
Field of Research: Cancer; Cell Biology; Signal transduction
Purification: Antigen affinity purification
Concentration: 0.7 mg/mL
Dilution: WB 1:500-1:2000; IHC 1:50-1:300
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 76 kDa
Observed Molecular Weight: Refer to figures
Isotype: IgG

Frequently Asked Questions

What is the catalog number for RIPK1 Polyclonal Antibody?

The catalog number for RIPK1 Polyclonal Antibody is E-AB-18284.

What sizes are available for RIPK1 Polyclonal Antibody?

RIPK1 Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does RIPK1 Polyclonal Antibody come in?

RIPK1 Polyclonal Antibody is available in 4 different pack sizes.

Is RIPK1 Polyclonal Antibody in stock?

RIPK1 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures RIPK1 Polyclonal Antibody?

RIPK1 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for RIPK1 Polyclonal Antibody?

Estimated delivery time for RIPK1 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for RIPK1 Polyclonal Antibody?

The safety data sheet for RIPK1 Polyclonal Antibody is available here: https://789.bio/eb/Xz5eL0.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.