PRNP Polyclonal Antibody

Specifications

Catalog number

E-AB-18439-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.

Abbreviation

PRNP

UniProt

P04156

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Fusion protein of human PRNP

Target

Alternative prion protein; major prion protein; AltPrP; ASCR; CD230; CD230 antigen; CJD; GSS; KURU; Major prion protein; p27 30; PRIO; Prion protein; Prion related protein; PRIP; PRNP; PrP; PrP27 30 ; PrP27-30; PrP33-35C; PrPC; PrPSc; Sinc

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Neuroscience; Stem cells

Purification

Antigen affinity purification

Concentration

0.6 mg/mL

Dilution

IHC 1:30-1:150

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG