PLGLB2 Polyclonal Antibody

Specifications

Catalog number

E-AB-18762-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cleavage of the serine proteinase plasminogen to form plasmin is the central event in the dissolution of blood clots by the fibrinolytic system. Within the fibrinolytic cascade, the serine proteinases urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) activate the proenzyme plasminogen by cleaving plasminogen to form the fibrinolytically active enzyme plasmin. PLGLB2 (plasminogen-like B2), also known as PLGP1, is a 96 amino acid protein that resembles the N-terminal plasminogen activation peptide, which is released from plasminogen during conversion to plasmin. PLGLB2 may bind to lysine binding sites present in the kringle structures of plasminogen, an event that interfers with the binding of fibrin or α-2 antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction.

Abbreviation

PLGLB2

UniProt

Q02325

Host

Rabbit

Reactivity

Human

Immunogen

Fusion protein of human PLGLB2

Target

Plasminogen-related protein B; PLGB; PLGLB2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Immunology; Signal transduction

Purification

Antigen affinity purification

Concentration

1.14 mg/mL

Dilution

IHC 1:50-1:300

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG