HBG1/HBG2 Polyclonal Antibody

Specifications

Catalog number

E-AB-18774-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1) . The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Abbreviation

HBG1/HBG2

UniProt

P69891, P69892

Host

Rabbit

Reactivity

Human

Immunogen

Fusion protein of human HBG1/HBG2

Target

A gamma globin; G gamma globin; Gamma 1 globin; Gamma 2 globin; Gamma A hemoglobin; Gamma globin; Hb F Agamma; Hb F Ggamma; hbfagamma; hbfggamma; HBG 1; HBG 2; HBG1; HBG2; HBGA; HBGR; Hemoglobin gamma 1 chain ; Hemoglobin gamma 2 chain ; Hemoglobin gamma A; Hemoglobin gamma A chain ; Hemoglobin gamma G; Hemoglobin gamma G chain ; Hemoglobin gamma regulator of; Hemoglobin subunit gamma 1; Hemoglobin subunit gamma 2; HSGGL 1; HSGGL1; Methemoglobin; PRO 2979; PRO2979

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cardiovascular

Purification

Antigen affinity purification

Concentration

0.6 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:40-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

16 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG