HLA-DRB1 Polyclonal Antibody

Catalog number E-AB-18811-01

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Price for E-AB-18811-01

Size / count 20 µL

Specifications

Catalog number: E-AB-18811-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Abbreviation: HLA-DRB1
UniProt: Q5Y7A7
Host: Rabbit
Reactivity: Human
Immunogen: Fusion protein of human HLA-DRB1
Target: MHC Class II HLA-DR Beta 1 Chain; Human Leucocyte Antigen DRB1; MHC Class II Antigen DRB1*10; MHC Class II Antigen DRB1*11; MHC Class II Antigen DRB1*12; MHC Class II Antigen DRB1*13; MHC Class II Antigen DRB1*14; MHC Class II Antigen DRB1*15; MHC Class II Antigen DRB1*16; MHC Class II Antigen DRB1*1; MHC Class II Antigen DRB1*3; MHC Class II Antigen DRB1*4; MHC Class II Antigen DRB1*7; MHC Class II Antigen DRB1*8; MHC Class II Antigen DRB1*9; Lymphocyte Antigen DRB1c
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC
Field of Research: Immunology
Purification: Antigen affinity purification
Concentration: 1.32 mg/mL
Dilution: WB 1:500-1:2000; IHC 1:50-1:300
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 30 kDa
Observed Molecular Weight: Refer to figures
Isotype: IgG

Frequently Asked Questions

What is the catalog number for HLA-DRB1 Polyclonal Antibody?

The catalog number for HLA-DRB1 Polyclonal Antibody is E-AB-18811.

What sizes are available for HLA-DRB1 Polyclonal Antibody?

HLA-DRB1 Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does HLA-DRB1 Polyclonal Antibody come in?

HLA-DRB1 Polyclonal Antibody is available in 4 different pack sizes.

Is HLA-DRB1 Polyclonal Antibody in stock?

HLA-DRB1 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HLA-DRB1 Polyclonal Antibody?

HLA-DRB1 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for HLA-DRB1 Polyclonal Antibody?

Estimated delivery time for HLA-DRB1 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HLA-DRB1 Polyclonal Antibody?

The safety data sheet for HLA-DRB1 Polyclonal Antibody is available here: https://789.bio/eb/084Sq9.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.