PSMD12 Polyclonal Antibody

Specifications

Catalog number

E-AB-18838-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Abbreviation

PSMD12

UniProt

O00232

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Fusion protein of human PSMD12

Target

26S proteasome non-ATPase regulatory subunit 12;26S proteasome regulatory subunit p55;26S proteasome regulatory subunit RPN5; MGC75406; p55; proteasome (prosome; macropain) 26S subunit; non ATPase12; Proteasome 26S non ATPase subunit 12 isoform 2; PSD12; PSMD12; Rpn5

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cell Biology

Purification

Antigen affinity purification

Concentration

0.72 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:40-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

53 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG