MLKL Polyclonal Antibody

Catalog number E-AB-18957-01

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Price for E-AB-18957-01

Size / count 20 µL

Specifications

Catalog number: E-AB-18957-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
Abbreviation: MLKL
UniProt: Q8NB16
Host: Rabbit
Reactivity: Human
Immunogen: Fusion protein of human MLKL
Target: 9130019I15Rik; FLJ34389; hMLKL; Mixed lineage kinase domain like; Mixed lineage kinase domain like protein; Mixed lineage kinase domain like pseudokinase; Mixed lineage kinase domain-like protein; Mlkl; MLKL
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Signal Transduction
Purification: Antigen affinity purification
Concentration: 1.5 mg/mL
Dilution: IHC 1:50-1:300
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for MLKL Polyclonal Antibody?

The catalog number for MLKL Polyclonal Antibody is E-AB-18957.

What sizes are available for MLKL Polyclonal Antibody?

MLKL Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does MLKL Polyclonal Antibody come in?

MLKL Polyclonal Antibody is available in 4 different pack sizes.

Is MLKL Polyclonal Antibody in stock?

MLKL Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MLKL Polyclonal Antibody?

MLKL Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for MLKL Polyclonal Antibody?

Estimated delivery time for MLKL Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MLKL Polyclonal Antibody?

The safety data sheet for MLKL Polyclonal Antibody is available here: https://789.bio/eb/mfr1a5.

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.