MRPL40 Polyclonal Antibody

Specifications

Catalog number

E-AB-19169-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.MRPL40 (Mitochondrial Ribosomal Protein L40) is a Protein Coding gene. Diseases associated with MRPL40 include Mrpl40-Related Disorder and Velocardiofacial Syndrome. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly (A) RNA binding.

Abbreviation

MRPL40

UniProt

Q9NQ50

Host

Rabbit

Reactivity

Human

Immunogen

Fusion protein of human MRPL40

Target

39S ribosomal protein L40;39S ribosomal protein L40 mitochondrial;39S ribosomal protein L40; mitochondrial precursor; FLJ41774; L40mt; MGC9400; mitochondrial; Mitochondrial ribosomal protein L40; MRP 40; MRP L22; MRP-L40; MRP40; MRPL22; MRPL40; NLVCF; Nuclear localization signal containing protein deleted in velocardiofacial syndrome; Nuclear localization signal deleted in velocardiofacial syndrome; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; RM40; Up-regulated in metastasis; URIM

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Epigenetics and Nuclear Signaling; Metabolism

Purification

Antigen affinity purification

Concentration

1.44 mg/mL

Dilution

WB 1:1000-1:5000; IHC 1:100-1:300

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

24 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG