DNAJA4 Polyclonal Antibody

Specifications

Catalog number

E-AB-19185-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. The proteins contain cysteine rich regions that are composed of zinc fingers that form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJA4 (DnaJ homolog subfamily A member 4) is a SREBP-regulated chaperone that is thought to regulate the cholesterol biosynthesis pathway.

Abbreviation

DNAJA4

UniProt

Q8WW22

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Fusion protein of human DNAJA4

Target

DnaJ (Hsp40) homolog subfamily A member 4; DnaJ (Hsp40) homolog; subfamily A; member4; DNAJ A4; DnaJ heat shock protein family (Hsp40) member A4; DnaJ homolog subfamily A member 4; DNAJA 4; DNAJA4; DNJA4; MST104; MSTP104; PRO1472

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cardiovascular; Metabolism; Signal transduction

Purification

Antigen affinity purification

Concentration

0.96 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

45 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG