EXOSC4 Polyclonal Antibody

Specifications

Catalog number

E-AB-19187-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.

Abbreviation

EXOSC4

UniProt

Q9NPD3

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Fusion protein of human EXOSC4

Target

EXOSC 4; Exosome complex component RRP41; Exosome complex exonuclease RRP41; Exosome component 4 ; Exosome component Rrp41 ; FLJ20591 ; hRrp41p; p12A ; Ribosomal RNA processing protein 41; RRP 41; RRP41; RRP41A ; Rrp41p ; SKI 6; SKI6 ; Ski6p

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Epigenetics and Nuclear Signaling

Purification

Antigen affinity purification

Concentration

0.84 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

26 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG