GLI1 Polyclonal Antibody

Specifications

Catalog number

E-AB-19459-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

GLI1 (GLI Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with GLI1 include Basal Cell Carcinoma and Necrobiosis Lipoidica. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and G-Beta Gamma Signaling. GO annotations related to this gene include chromatin binding and microtubule binding. An important paralog of this gene is GLI2. This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.

Abbreviation

GLI1

UniProt

P08151

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Synthetic peptide of human GLI1

Target

Gli 1; GLI; GLI family zinc finger 1; GLI Kruppel family member 1; gli1; GLI1; Glioma associated oncogene 1; Glioma associated oncogene homolog 1 (zinc finger protein) ; Glioma associated oncogene homolog; Glioma-associated oncogene; Oncogene GLI; Zfp 5; Zfp5; Zinc finger protein GLI 1; Zinc finger protein GLI1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Epigenetics and Nuclear Signaling; Neuroscience; Stem Cells

Purification

Antigen affinity purification

Concentration

1.08 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:100

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

118 kDa

Observed Molecular Weight

Refer to figures

Citation 01

https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29636

Isotype

IgG