Phospho-Catenin beta (Ser37) Polyclonal Antibody

Specifications

Catalog number

E-AB-20828-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Abbreviation

Catenin-β (phospho Ser37)

UniProt

P35222

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human Catenin-β around the phosphorylation site of Ser37

Target

Beta catenin; Beta-catenin; Cadherin associated protein; Catenin (cadherin associated protein) ; beta 1;88kDa; Catenin beta 1; Catenin beta-1; CATNB; CHBCAT; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC-p; IF

Field of Research

Cancer; Cardiovascular; Neuroscience; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000

Buffer

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

85kDa

Observed Molecular Weight

85kDa

Citation 01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523073/

Isotype

IgG