CASP8 Monoclonal Antibody

Catalog number E-AB-22107-01

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Price for E-AB-22107-01

Size / count 20 µL

Specifications

Catalog number: E-AB-22107-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Abbreviation: Caspase-8
UniProt: Q14790
Host: Mouse
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant Protein
Target: ALPS2B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein; Apoptotic cysteine protease; Apoptotic protease Mch-5; Apoptotic protease Mch5; CAP4; CASP-8; CASP8; CASP8; Caspase 8; Caspase 8 apoptosis related cysteine peptidase; Caspase-8 subunit p10; CED 3; FADD Like ICE; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; FLJ17672; ICE-like apoptotic protease 5; MACH alpha 1/2/3 protein; MACH; MACH beta 1/2/3/4 protein; MCH5; MGC78473; MORT1 associated ced 3 homolog; MORT1-associated CED-3 homolog; OTTHUMP00000163717; OTTHUMP00000163720; OTTHUMP00000163724; OTTHUMP00000163725; OTTHUMP00000165062; OTTHUMP00000165063; OTTHUMP00000165064; OTTHUMP00000206552; OTTHUMP00000206582
Clonality: Monoclonal
Clone: Clone:2E3
Conjugation: Unconjugated
Applications: WB; IHC-p; IF
Field of Research: Cancer; Cell Biology; Metabolism
Purification: Protein A purification
Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:100-1:300
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight: 43,57kDa
Citation 01: https://www.frontiersin.org/articles/10.3389/fonc.2021.735183/full
Citation 02: https://www.mdpi.com/1422-0067/23/18/10411
Citation 03: https://www.nature.com/articles/s41419-018-0449-5
Citation 04: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jat.4286
Isotype: IgG

Frequently Asked Questions

What is the catalog number for CASP8 Monoclonal Antibody?

The catalog number for CASP8 Monoclonal Antibody is E-AB-22107.

What sizes are available for CASP8 Monoclonal Antibody?

CASP8 Monoclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does CASP8 Monoclonal Antibody come in?

CASP8 Monoclonal Antibody is available in 4 different pack sizes.

Is CASP8 Monoclonal Antibody in stock?

CASP8 Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CASP8 Monoclonal Antibody?

CASP8 Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for CASP8 Monoclonal Antibody?

Estimated delivery time for CASP8 Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CASP8 Monoclonal Antibody?

The safety data sheet for CASP8 Monoclonal Antibody is available here: https://789.bio/eb/4mz9a5.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.