Active CASP3 Monoclonal Antibody

Catalog number E-AB-22115-01

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Price for E-AB-22115-01

Size / count 20 µL

Specifications

Catalog number: E-AB-22115-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Abbreviation: Active Caspase-3
UniProt: P42574
Host: Mouse
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant Protein
Target: A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama
Clonality: Monoclonal
Clone: Clone:5A2
Conjugation: Unconjugated
Applications: WB; IHC-p; IF
Field of Research: Cancer; Cell Biology; Metabolism; Neuroscience
Purification: Protein A purification
Concentration: 1 mg/mL
Dilution: WB 1:500-1:1000; IHC 1:100-1:200; IF 1:100-1:200
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight: 17kDa
Citation 01: https://www.sciencedirect.com/science/article/pii/S2162253122003006
Citation 02: https://www.mdpi.com/1806946
Citation 03: https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo01547h
Citation 04: https://www.sciencedirect.com/science/article/pii/S1382668920300880
Citation 05: https://www.sciencedirect.com/science/article/pii/S0161813X18304170
Citation 06: https://www.spandidos-publications.com/10.3892/ol.2018.9635?text=abstract
Citation 07: https://link.springer.com/article/10.1134/S0022093021060120
Isotype: IgG

Frequently Asked Questions

What is the catalog number for Active CASP3 Monoclonal Antibody?

The catalog number for Active CASP3 Monoclonal Antibody is E-AB-22115.

What sizes are available for Active CASP3 Monoclonal Antibody?

Active CASP3 Monoclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does Active CASP3 Monoclonal Antibody come in?

Active CASP3 Monoclonal Antibody is available in 4 different pack sizes.

Is Active CASP3 Monoclonal Antibody in stock?

Active CASP3 Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Active CASP3 Monoclonal Antibody?

Active CASP3 Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for Active CASP3 Monoclonal Antibody?

Estimated delivery time for Active CASP3 Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Active CASP3 Monoclonal Antibody?

The safety data sheet for Active CASP3 Monoclonal Antibody is available here: https://789.bio/eb/TKCKSC.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.