TNF alpha Monoclonal Antibody

Catalog number E-AB-22116-01

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Price for E-AB-22116-01

Size / count 20 µL

Specifications

Catalog number: E-AB-22116-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Abbreviation: TNF α
UniProt: P01375
Host: Mouse
Reactivity: Human; Mouse; Rat
Immunogen: Synthetic Peptide
Target: APC1; APC1 protein; Cachectin; DIF; Differentiation inducing factor; Macrophage cytotoxic factor; Tnf; TNF superfamily; member 2; TNF; macrophage derived; TNF; monocyte derived; TNF-a; TNF-alpha; TNFA; TNFA; TNFSF2; Tumor necrosis factor alpha; Tumor necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor Necrosis Factor; Membrane Form; Tumor necrosis factor; soluble form
Clonality: Monoclonal
Clone: Clone:3D8
Conjugation: Unconjugated
Applications: WB; IHC-p
Field of Research: Cancer; Cardiovascular; Metabolism; Immunology; Signal Transduction
Purification: Protein A purification
Concentration: 1 mg/mL
Dilution: WB 1:1000-1:3000; IHC 1:50-1:200
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight: 17,25kDa
Citation 01: https://www.sciencedirect.com/science/article/pii/S1567576920300564
Isotype: IgG

Frequently Asked Questions

What is the catalog number for TNF alpha Monoclonal Antibody?

The catalog number for TNF alpha Monoclonal Antibody is E-AB-22116.

What sizes are available for TNF alpha Monoclonal Antibody?

TNF alpha Monoclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does TNF alpha Monoclonal Antibody come in?

TNF alpha Monoclonal Antibody is available in 4 different pack sizes.

Is TNF alpha Monoclonal Antibody in stock?

TNF alpha Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TNF alpha Monoclonal Antibody?

TNF alpha Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for TNF alpha Monoclonal Antibody?

Estimated delivery time for TNF alpha Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TNF alpha Monoclonal Antibody?

The safety data sheet for TNF alpha Monoclonal Antibody is available here: https://789.bio/eb/WvbfLC.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.