GSK3 beta Monoclonal Antibody

Catalog number E-AB-22130-01

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Price for E-AB-22130-01

Size / count 20 µL

Specifications

Catalog number: E-AB-22130-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Abbreviation: GSK3 beta
UniProt: P49841
Host: Mouse
Reactivity: Human; Mouse; Rat
Immunogen: Synthetic Peptide of GSK3β
Target: Glycogen Synthase Kinase 3 Beta; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK-3 beta; GSK3B; GSK3B; GSK3beta isoform; Serine/threonine-protein kinase GSK3B
Clonality: Monoclonal
Clone: Clone:4C3
Conjugation: Unconjugated
Applications: WB; IHC-p
Field of Research: Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Purification: Protein A purification
Concentration: 1 mg/mL
Dilution: WB 1:1000-2000; IHC 1:100-200
Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Observed Molecular Weight: 46kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for GSK3 beta Monoclonal Antibody?

The catalog number for GSK3 beta Monoclonal Antibody is E-AB-22130.

What sizes are available for GSK3 beta Monoclonal Antibody?

GSK3 beta Monoclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does GSK3 beta Monoclonal Antibody come in?

GSK3 beta Monoclonal Antibody is available in 4 different pack sizes.

Is GSK3 beta Monoclonal Antibody in stock?

GSK3 beta Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GSK3 beta Monoclonal Antibody?

GSK3 beta Monoclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for GSK3 beta Monoclonal Antibody?

Estimated delivery time for GSK3 beta Monoclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for GSK3 beta Monoclonal Antibody?

The safety data sheet for GSK3 beta Monoclonal Antibody is available here: https://789.bio/eb/CyTqrH.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.