Cleaved-CASP3 p12 (D175) Polyclonal Antibody

Catalog number E-AB-30003-01

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Price for E-AB-30003-01

Size / count 20 µL

Specifications

Catalog number: E-AB-30003-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Abbreviation: Cleaved-Caspase-3 p12 (D175)
UniProt: P42574
Host: Rabbit
Reactivity: Human
Immunogen: Synthesized peptide derived from the Internal region of human Caspase-3 p12
Target: A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC-p; IF
Field of Research: Cancer; Cell Biology; Metabolism; Neuroscience
Purification: Affinity purification
Concentration: 1mg/mL
Dilution: WB 1:500-2000; IHC 1:50-300; IF 1:50-300
Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 32kDa
Observed Molecular Weight: 20+35kDa
Citation 01: https://www.nature.com/articles/s41590-022-01166-6
Citation 02: https://static.frontiersin.org/articles/10.3389/fmolb.2022.816510/full
Citation 03: https://www.frontiersin.org/articles/10.3389/fphar.2021.646953/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FPHAR_XXXXXXXX_auto-dlvrit
Citation 04: https://www.worldscientific.com/doi/abs/10.1142/S0192415X21500245
Citation 05: https://www.sciencedirect.com/science/article/pii/S094471131630191X
Isotype: IgG

Frequently Asked Questions

What is the catalog number for Cleaved-CASP3 p12 (D175) Polyclonal Antibody?

The catalog number for Cleaved-CASP3 p12 (D175) Polyclonal Antibody is E-AB-30003.

What sizes are available for Cleaved-CASP3 p12 (D175) Polyclonal Antibody?

Cleaved-CASP3 p12 (D175) Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does Cleaved-CASP3 p12 (D175) Polyclonal Antibody come in?

Cleaved-CASP3 p12 (D175) Polyclonal Antibody is available in 4 different pack sizes.

Is Cleaved-CASP3 p12 (D175) Polyclonal Antibody in stock?

Cleaved-CASP3 p12 (D175) Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cleaved-CASP3 p12 (D175) Polyclonal Antibody?

Cleaved-CASP3 p12 (D175) Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for Cleaved-CASP3 p12 (D175) Polyclonal Antibody?

Estimated delivery time for Cleaved-CASP3 p12 (D175) Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cleaved-CASP3 p12 (D175) Polyclonal Antibody?

The safety data sheet for Cleaved-CASP3 p12 (D175) Polyclonal Antibody is available here: https://789.bio/eb/0yH4SS.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.