Product details

EGFR Polyclonal Antibody

Catalog number E-AB-31291-01

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Price for E-AB-31291-01

Size / count 20 µL

Specifications

Catalog number: E-AB-31291-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.
Abbreviation: EGFR
UniProt: P00533
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Synthesized peptide derived from human EGFR around the non-phosphorylation site of Tyr1016.
Target: Avian erythroblastic leukemia viral (v erb b) oncogene homolog; Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; EGFR; Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) ; Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) ; Epidermal growth factor receptor; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; Errp; HER1; mENA; NISBD2; Oncogen ERBB; PIG61; Proto-oncogene c-ErbB-1; Receptor tyrosine protein kinase ErbB 1; Receptor tyrosine-protein kinase ErbB-1; SA7; Species antigen 7; Urogastrone; v-erb-b Avian erythroblastic leukemia viral oncogen homolog; wa2; Wa5
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC-p; IF
Field of Research: Cancer; Signal Transduction
Purification: Affinity purification
Concentration: 1mg/mL
Dilution: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000
Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 134kDa
Observed Molecular Weight: 134kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for EGFR Polyclonal Antibody?

The catalog number for EGFR Polyclonal Antibody is E-AB-31291.

What sizes are available for EGFR Polyclonal Antibody?

EGFR Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does EGFR Polyclonal Antibody come in?

EGFR Polyclonal Antibody is available in 4 different pack sizes.

Is EGFR Polyclonal Antibody in stock?

EGFR Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EGFR Polyclonal Antibody?

EGFR Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for EGFR Polyclonal Antibody?

Estimated delivery time for EGFR Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for EGFR Polyclonal Antibody?

The safety data sheet for EGFR Polyclonal Antibody is available here: https://789.bio/eb/5aDq1O.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.