SMAD4 Polyclonal Antibody

Catalog number E-AB-34159-01

Choose a variant (4 options)

Selecting a variant updates its price, size and availability.

Price for E-AB-34159-01

Size / count 20 µL

Specifications

Catalog number: E-AB-34159-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE) . The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. SMAD4 (SMAD Family Member 4) is a Protein Coding gene. Diseases associated with SMAD4 include Myhre Syndrome and Polyposis, Juvenile Intestinal. Among its related pathways are PEDF Induced Signaling and Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is SMAD9.
Abbreviation: Smad4
UniProt: Q13485
Host: Rabbit
Reactivity: Human; Mouse; Rat; Monkey
Immunogen: Synthesized peptide derived from the N-terminal region of human Smad4
Target: (Small) Mothers Against Decapentaplegic; Deleted in Pancreatic Carcinoma 4; Deleted in Pancreatic Carcinoma; Deleted in pancreatic carcinoma locus 4; Deletion target in pancreatic carcinoma 4; DPC 4; DPC4; hSMAD4; JIP; MAD homolog 4; MAD mothers against decapentaplegic Drosophila homolog 4; MAD mothers against decapentaplegic homolog 4; MADH 4; MADH4; Med; Medea; Mothers against decapentaplegic homolog 4; Mothers against decapentaplegic; Drosophila; homolog of;4; Mothers against DPP homolog 4; MYHRS; OTTHUMP00000163548; SMA- and MAD-related protein 4; SMAD 4; SMAD family member 4; SMAD mothers against DPP homolog 4; SMAD4; SMAD4
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC-p; IF
Field of Research: Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction; Stem Cells
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution: IHC 1:100-1:300; IF 1:200-1:1000
Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 60kDa
Observed Molecular Weight: 60kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for SMAD4 Polyclonal Antibody?

The catalog number for SMAD4 Polyclonal Antibody is E-AB-34159.

What sizes are available for SMAD4 Polyclonal Antibody?

SMAD4 Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does SMAD4 Polyclonal Antibody come in?

SMAD4 Polyclonal Antibody is available in 4 different pack sizes.

Is SMAD4 Polyclonal Antibody in stock?

SMAD4 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SMAD4 Polyclonal Antibody?

SMAD4 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for SMAD4 Polyclonal Antibody?

Estimated delivery time for SMAD4 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SMAD4 Polyclonal Antibody?

The safety data sheet for SMAD4 Polyclonal Antibody is available here: https://789.bio/eb/rLyjb9.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.