FAS Polyclonal Antibody

Specifications

Catalog number

E-AB-40063-01

Size / count

25 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC) . FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.

Abbreviation

FAS

UniProt

P25445

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein

Target

ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; Fas (TNF receptor superfamily; member 6) ; FAS 1; FAS 827dupA; Fas AMA; Fas; FAS Antigen; Fas cell surface death receptor; FAS1; FASLG receptor; FASTM; sFAS; Surface antigen APO1; TNF receptor superfamily; member 6; TNFRSF 6; TNFRSF6; TNR6; Tumor necrosis factor receptor superfamily member 6

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cell Biology; Immunology

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; IHC 1:50-1:100

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

37kDa

Observed Molecular Weight

45kDa

Citation 01

https://www.frontiersin.org/articles/10.3389/fonc.2021.735183/full

Citation 02

https://www.mdpi.com/1422-0067/20/3/757

Citation 03

https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.22942

Citation 04

https://www.sciencedirect.com/science/article/pii/S0006291X19316687

Isotype

IgG