BBC3 Polyclonal Antibody

Specifications

Catalog number

E-AB-40332-01

Size / count

25 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Abbreviation

BBC3

UniProt

Q9BXH1

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human Bcl-2-binding component 3 protein

Target

BBC 3; Bbc3; BBC3; BCL 2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; JFY 1; JFY-1; JFY1; p53 up regulated modulator of apoptosis; p53 up-regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cell Biology; Metabolism; Signal Transduction

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1000; IHC 1:100-1:200

Buffer

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

21kDa

Observed Molecular Weight

26kDa

Isotype

IgG