GRP78 Polyclonal Antibody

Catalog number E-AB-40588-01

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Price for E-AB-40588-01

Size / count 25 µL

Specifications

Catalog number: E-AB-40588-01
Size / count: 25 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: GRP78 (Glucose-regulated protein 78 kDa; also BiP and HSPA5) is a 72 kDa member of the heat shock protein 70 family of proteins. Intracellularly, GRP78 is an endoplasmic reticulum chaperone that participates in protein folding; extracellularly, it induces IL-10 production from T cells and interacts with Cripto to block TGF-beta signaling. Human GRP78 precursor is 654 amino acids (aa) in length. It contains an 18 aa signal sequence and a 636 aa mature region that shows a hydantoinase A region (aa 145245) and a C-terminal KDEL motif that is present on intracellular GRP78, but absent on secreted GRP78. There is alternative splicing in the signal sequence (aa 110), and multiple single aa substitituion. Over aa 1654, human GRP78 is more than 97% aa identical to mouse and rat GRP78.
Abbreviation: GRP78
UniProt: P11021
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant Human GRP78 protein expressed by E.coli.
Target: BiP; GRP-78; HSP70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein; HSPA5
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB
Field of Research: Cancer; Tags and Cell Markers
Purification: Antigen Affinity Purification
Concentration: 1 mg/mL
Dilution: WB 1:500-1000
Buffer: PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 72kDa
Observed Molecular Weight: 78kDa
Citation 01: https://www.spandidos-publications.com/10.3892/ijmm.2019.4432
Isotype: IgG

Frequently Asked Questions

What is the catalog number for GRP78 Polyclonal Antibody?

The catalog number for GRP78 Polyclonal Antibody is E-AB-40588.

What sizes are available for GRP78 Polyclonal Antibody?

GRP78 Polyclonal Antibody is available in the following size(s): 25 µL, 100 µL.

How many pack sizes does GRP78 Polyclonal Antibody come in?

GRP78 Polyclonal Antibody is available in 2 different pack sizes.

Is GRP78 Polyclonal Antibody in stock?

GRP78 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GRP78 Polyclonal Antibody?

GRP78 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for GRP78 Polyclonal Antibody?

Estimated delivery time for GRP78 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for GRP78 Polyclonal Antibody?

The safety data sheet for GRP78 Polyclonal Antibody is available here: https://789.bio/eb/ff5W1O.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.