FKBPL Polyclonal Antibody

Catalog number E-AB-52239-01

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Price for E-AB-52239-01

Size / count 20 µL

Specifications

Catalog number: E-AB-52239-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: FKBPL, also named as DIR1, NG7 and WISp39, has similarity to the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance, probably by increasing the rate of DNA repair in cells exposed to X rays. Also it appears to have some involvement in general stress response in the control of the cell cycle. It regulates p21 protein stability by binding to Hsp90 and p21. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant, whereas FKBPL knockdown reverses this phenotype. FKBPL is an estrogen-inducible gene that acts as a cochaperone in ERα/Hsp90 molecular complexes; furthermore, FKBPL levels may be both a prognostic indicator and determinant of response to endocrine therapy.
Abbreviation: FKBPL
UniProt: Q9UIM3
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Fusion protein of human FKBPL
Target: DIR1; FK506 binding protein like; FK506-binding protein-like; Fkbpl; FKBPL; NG7; OTTHUMP00000029170; WAF 1/CIP1 stabilizing protein 39; WAF-1/CIP1 stabilizing protein 39; WISP39
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cell Biology; Epigenetics and Nuclear Signaling; Signal Transduction
Purification: Antigen affinity purification
Concentration: 1.3 mg/mL
Dilution: IHC 1:30-1:150
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for FKBPL Polyclonal Antibody?

The catalog number for FKBPL Polyclonal Antibody is E-AB-52239.

What sizes are available for FKBPL Polyclonal Antibody?

FKBPL Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does FKBPL Polyclonal Antibody come in?

FKBPL Polyclonal Antibody is available in 4 different pack sizes.

Is FKBPL Polyclonal Antibody in stock?

FKBPL Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures FKBPL Polyclonal Antibody?

FKBPL Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for FKBPL Polyclonal Antibody?

Estimated delivery time for FKBPL Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for FKBPL Polyclonal Antibody?

The safety data sheet for FKBPL Polyclonal Antibody is available here: https://789.bio/eb/Smb1i1.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.