COA7 Polyclonal Antibody

Specifications

Catalog number

E-AB-52496-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. COA7 (cytochrome c oxidase assembly factor 7), also known as RESA1, SELRC1 or C1orf163, is a 231 amino acid mitochondrial protein that belongs to the hcp beta-lactamase family. Consisting of five Sel1-like repeats, COA7 may be associated with respiratory chain assembly. COA7 is encoded by a gene located on human chromosome 1p32.3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene, which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.

Abbreviation

COA7

UniProt

Q96BR5

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Full length fusion protein

Target

Beta-lactamase hcp-like protein; C1orf163; Chromosome 1 open reading frame 163; FLJ12439; Hcp beta lactamase like protein C1orf163; Hypothetical protein LOC65260; RESA1; Sel1 repeat containing 1; sel1 repeat-containing protein 1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cell Biology

Purification

Antigen affinity purification

Concentration

0.9 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:40-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

26 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG