ATP6V1C1 Polyclonal Antibody

Specifications

Catalog number

E-AB-52927-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.

Abbreviation

ATP6V1C1

UniProt

P21283

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Fusion protein of human ATP6V1C1

Target

ATP6C; ATP6D ; ATP6V1C1; ATPase H+ transporting lysosomal (vacuolar proton pump) 42kD; ATPase H+ transporting lysosomal 42kD V1 subunit C isoform 1; ATPase H+ transporting lysosomal 42kDa V1 subunit C isoform 1; ATPase H+ transporting lysosomal 42kDa V1 subunit C1 ; ATPase H+ transporting lysosomal V1 subunit C1; FLJ20057; H (+) transporting two sector ATPase subunit C; H+ ATPase C subunit ; H+ transporting ATPase chain C vacuolar ; Subunit C of vacuolar proton ATPase V1 domain; V ATPase C subunit ; V ATPase subunit C 1; V-ATPase subunit C 1; V-type proton ATPase subunit C 1; Vacuolar ATP synthase subunit C; Vacuolar proton pump 42 kD subunit ; Vacuolar proton pump C subunit ; Vacuolar proton pump subunit C 1; Vacuolar protonATPase subunit C VI domain ; VATC; VATC1; VATPase C subunit ; VATPase subunit C 1; VMA5

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Metabolism; Signal transduction

Purification

Antigen affinity purification

Concentration

0.66 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

44 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG