SRPK2 Polyclonal Antibody

Specifications

Catalog number

E-AB-53007-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Abbreviation

SRPK2

UniProt

P78362

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Fusion protein of human SRPK2

Target

Human serine kinase SRPK2 mRNA; complete cds; Serine kinase SRPK2; Serine/arginine rich protein specific kinase 2; Serine/arginine-rich protein-specific kinase 2; Serine/threonine protein kinase SRPK2 ; SFRS protein kinase 2; SFRSK2 ; SR protein specific kinase 2; SR-protein-specific kinase 2; SRPK2; SRPK2; SRSF protein kinase 2 C-terminal

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Purification

Antigen affinity purification

Concentration

0.96 mg/mL

Dilution

IHC 1:50-1:200

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG