TNNT1 Polyclonal Antibody

Specifications

Catalog number

E-AB-53126-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.

Abbreviation

TNNT1

UniProt

P13805

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Fusion protein of human TNNT1

Target

ANM; MGC104241; NEM5; Skeletal; Slow ; slow skeletal muscle; Slow skeletal muscle troponin T; sTnT; Tnnt1; TNNT1; TNT; TnTs; Troponin T; Troponin T slow skeletal muscle; Troponin T type 1 (skeletal slow) ; troponin T1 skeletal slow; Troponin T1; slow skeletal type

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Signal transduction

Purification

Antigen affinity purification

Concentration

0.66 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:25-1:50

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

33 kDa

Observed Molecular Weight

Refer to figures

Isotype

IgG