ATXN7 Polyclonal Antibody

Catalog number E-AB-53584-01

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Price for E-AB-53584-01

Size / count 20 µL

Specifications

Catalog number: E-AB-53584-01
Size / count: 20 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.
Abbreviation: ATXN7
UniProt: O15265
Host: Rabbit
Reactivity: Human; Mouse
Immunogen: Synthetic peptide of human ATXN7
Target: ADCAII; ATXN 7; OPCA III; OPCA3; SCA 7; SCA7; Spinocerebellar Ataxia 7; Spinocerebellar ataxia type 7 protein
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Neuroscience
Purification: Antigen affinity purification
Concentration: 0.9 mg/mL
Dilution: IHC 1:50-1:300
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for ATXN7 Polyclonal Antibody?

The catalog number for ATXN7 Polyclonal Antibody is E-AB-53584.

What sizes are available for ATXN7 Polyclonal Antibody?

ATXN7 Polyclonal Antibody is available in the following size(s): 20 µL, 60 µL, 120 µL, 200 µL.

How many pack sizes does ATXN7 Polyclonal Antibody come in?

ATXN7 Polyclonal Antibody is available in 4 different pack sizes.

Is ATXN7 Polyclonal Antibody in stock?

ATXN7 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ATXN7 Polyclonal Antibody?

ATXN7 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for ATXN7 Polyclonal Antibody?

Estimated delivery time for ATXN7 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ATXN7 Polyclonal Antibody?

The safety data sheet for ATXN7 Polyclonal Antibody is available here: https://789.bio/eb/rrTOK4.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.