Product details

RAF1 Polyclonal Antibody

Catalog number E-AB-60020-01

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Price for E-AB-60020-01

Size / count 60 µL

Specifications

Catalog number: E-AB-60020-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene is the cellular homolog of viral raf gene (v-raf) . The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Abbreviation: RAF1
UniProt: P04049
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant fusion protein of human RAF1 (NP_002871.1) .
Target: CMD1NN; CRAF; NS5; Raf-1; c-Raf; RAF1
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC; IF
Field of Research: Cancer; Cell Biology; Metabolism; Signal Transduction
Purification: Affinity purification
Concentration: 1mg/mL
Dilution: WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 73kDa/75kDa
Observed Molecular Weight: 73kDa
Citation 01: https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.16359
Isotype: IgG

Frequently Asked Questions

What is the catalog number for RAF1 Polyclonal Antibody?

The catalog number for RAF1 Polyclonal Antibody is E-AB-60020.

What sizes are available for RAF1 Polyclonal Antibody?

RAF1 Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does RAF1 Polyclonal Antibody come in?

RAF1 Polyclonal Antibody is available in 3 different pack sizes.

Is RAF1 Polyclonal Antibody in stock?

RAF1 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures RAF1 Polyclonal Antibody?

RAF1 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for RAF1 Polyclonal Antibody?

Estimated delivery time for RAF1 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for RAF1 Polyclonal Antibody?

The safety data sheet for RAF1 Polyclonal Antibody is available here: https://789.bio/eb/inbbH8.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.