(KO Validated) Caspase-3 Polyclonal Antibody — image 1 of 3

Product details

(KO Validated) Caspase-3 Polyclonal Antibody

Catalog number E-AB-60646-01

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Price for E-AB-60646-01

Size / count 60 µL

Specifications

Catalog number: E-AB-60646-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Abbreviation: Caspase-3
UniProt: P42574
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant fusion protein of human Caspase-3 (NP_004337.2) .
Target: CPP32; CPP32B; SCA-1; Active Caspase 3; CASP3; active Caspase-3; Caspase 3; Caspase-3 p12; caspase-3
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IHC
Field of Research: Cancer; Cell Biology; Metabolism; Neuroscience
Purification: Affinity purification
Concentration: 1mg/mL
Dilution: WB 1:500-1:2000; IHC 1:50-1:200
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 31kDa
Observed Molecular Weight: 17kDa/35kDa
Citation 01: https://www.spandidos-publications.com/or/37/2/1270
Citation 02: https://www.spandidos-publications.com/10.3892/or.2016.4811
Citation 03: https://link.springer.com/article/10.1007/s40200-022-01132-x
Isotype: IgG

Frequently Asked Questions

What is the catalog number for (KO Validated) Caspase-3 Polyclonal Antibody?

The catalog number for (KO Validated) Caspase-3 Polyclonal Antibody is E-AB-60646.

What sizes are available for (KO Validated) Caspase-3 Polyclonal Antibody?

(KO Validated) Caspase-3 Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does (KO Validated) Caspase-3 Polyclonal Antibody come in?

(KO Validated) Caspase-3 Polyclonal Antibody is available in 3 different pack sizes.

Is (KO Validated) Caspase-3 Polyclonal Antibody in stock?

(KO Validated) Caspase-3 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures (KO Validated) Caspase-3 Polyclonal Antibody?

(KO Validated) Caspase-3 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for (KO Validated) Caspase-3 Polyclonal Antibody?

Estimated delivery time for (KO Validated) Caspase-3 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for (KO Validated) Caspase-3 Polyclonal Antibody?

The safety data sheet for (KO Validated) Caspase-3 Polyclonal Antibody is available here: https://789.bio/eb/1WjzvL.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.