DNMT3B Polyclonal Antibody

Specifications

Catalog number

E-AB-60798-01

Size / count

60 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Abbreviation

DNMT3B

UniProt

Q9UBC3

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide of human DNMT3B

Target

DNMT3B; ICF; ICF1; M.HsaIIIB

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IF

Field of Research

Cancer; Epigenetics and Nuclear Signaling

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:200-1:1000; IF 1:50-1:200

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

77-95kDa

Observed Molecular Weight

110kDa

Isotype

IgG