PTEN Polyclonal Antibody

Catalog number E-AB-63495-01

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Price for E-AB-63495-01

Size / count 60 µL

Specifications

Catalog number: E-AB-63495-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Abbreviation: PTEN
UniProt: P60484
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant fusion protein of human PTEN (NP_000305.3) .
Target: 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1; PTEN; PTENbeta
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IF
Field of Research: Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction
Purification: Affinity purification
Concentration: 1mg/mL
Dilution: WB 1:500-1:2000; IF 1:50-1:200
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 19kDa/47kDa/64kDa
Observed Molecular Weight: 58kDa
Isotype: IgG

Frequently Asked Questions

What is the catalog number for PTEN Polyclonal Antibody?

The catalog number for PTEN Polyclonal Antibody is E-AB-63495.

What sizes are available for PTEN Polyclonal Antibody?

PTEN Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does PTEN Polyclonal Antibody come in?

PTEN Polyclonal Antibody is available in 3 different pack sizes.

Is PTEN Polyclonal Antibody in stock?

PTEN Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PTEN Polyclonal Antibody?

PTEN Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for PTEN Polyclonal Antibody?

Estimated delivery time for PTEN Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for PTEN Polyclonal Antibody?

The safety data sheet for PTEN Polyclonal Antibody is available here: https://789.bio/eb/Ti9uz5.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.