(KO Validated) BAX Polyclonal Antibody

Specifications

Catalog number

E-AB-63606-01

Size / count

60 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Abbreviation

BAX

UniProt

Q07812

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide of human BAX (NP_620116.1) .

Target

BCL2L4; BAX

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cell Biology; Metabolism

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000; IHC 1:100-1:200

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

4kDa/12kDa/15kDa/18kDa/19kDa/21kDa/24kDa

Observed Molecular Weight

20kDa

Citation 01

https://www.sciencedirect.com/science/article/pii/S1382668922001739

Citation 02

https://www.sciencedirect.com/science/article/pii/S0960076018302851

Isotype

IgG