Product details

P21 Polyclonal Antibody

Catalog number E-AB-66357-01

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Price for E-AB-66357-01

Size / count 60 µL

Specifications

Catalog number: E-AB-66357-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
Abbreviation: P21
UniProt: P38936
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: Recombinant fusion protein of human p21 (NP_000380.1) .
Target: CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1; CDKN1A
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: WB; IF
Field of Research: Cell Biology; Epigenetics and Nuclear Signaling; Signal Transduction
Purification: Affinity purification
Concentration: 1mg/mL
Dilution: WB 1:500-1:2000; IF 1:50-1:200
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight: 21kDa
Observed Molecular Weight: 21kDa
Citation 01: https://www.nature.com/articles/s41467-022-28721-x
Citation 02: https://www.mdpi.com/1574002
Citation 03: https://www.future-science.com/doi/abs/10.2144/btn-2022-0046
Isotype: IgG

Frequently Asked Questions

What is the catalog number for P21 Polyclonal Antibody?

The catalog number for P21 Polyclonal Antibody is E-AB-66357.

What sizes are available for P21 Polyclonal Antibody?

P21 Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does P21 Polyclonal Antibody come in?

P21 Polyclonal Antibody is available in 3 different pack sizes.

Is P21 Polyclonal Antibody in stock?

P21 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P21 Polyclonal Antibody?

P21 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for P21 Polyclonal Antibody?

Estimated delivery time for P21 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P21 Polyclonal Antibody?

The safety data sheet for P21 Polyclonal Antibody is available here: https://789.bio/eb/Wz90GK.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.