INS Polyclonal Antibody

Specifications

Catalog number

E-AB-67409-01

Size / count

60 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Abbreviation

INS

UniProt

P01308

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant fusion protein of human INS (NP_000198.1) .

Target

IDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10; INS; Insulin; insulin

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC; IF

Field of Research

Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction

Purification

Affinity purification

Concentration

1mg/mL

Dilution

IHC 1:50-1:200; IF 1:50-1:200

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG