Caspase-1 Polyclonal Antibody

Specifications

Catalog number

E-AB-68259-01

Size / count

60 μL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

Abbreviation

Caspase-1

UniProt

P29466

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Recombinant fusion protein of human Caspase-1

Target

CASP1; ICE; IL1BC; P45; caspase-1; Caspase 1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IF

Field of Research

Cancer; Cell Biology; Metabolism

Purification

Affinity purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IF 1:50-1:200

Buffer

PBS with 0.01% thiomersal,50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

10kDa/29kDa/35kDa/42kDa/45kDa

Observed Molecular Weight

48KDa

Isotype

IgG