P21 Polyclonal Antibody

Catalog number E-AB-70068-01

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Price for E-AB-70068-01

Size / count 60 µL

Specifications

Catalog number: E-AB-70068-01
Size / count: 60 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: CDKN1A (p21, CIP1, WAF1), a cyclin-dependent kinase inhibitor, is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase (CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.
Abbreviation: P21
UniProt: P38936, P39689
Host: Rabbit
Reactivity: Human; Mouse; Rat
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse P21
Target: CAP20; CDK-interacting protein 1; CDKI; CDKN1; Cdkn1a; CDN1A; CIP1; Cyclin Dependent Kinase Inhibitor 1A; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (P21) ; Cyclin-dependent kinase inhibitor 1A (p21; Cip1) ; DNA Synthesis Inhibitor; MDA-6; MDA6; Melanoma differentiation-associated protein 6; Melanoma differentiation-associated protein; p21; P21 protein; p21CIP1; p21Cip1/Waf1; p21WAF; PIC1; SDI1; SLC12A9; WAF1; Wild type p53 activated fragment 1 (WAF1) ; Wild type p53 activated fragment 1; Wildtype p53-activated fragment 1
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Field of Research: Cancer; Cell Biology; Epigenetics and Nuclear Signaling
Purification: Affinity purification
Concentration: 0.7 mg/mL
Dilution: IHC 1:200-1:800
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for P21 Polyclonal Antibody?

The catalog number for P21 Polyclonal Antibody is E-AB-70068.

What sizes are available for P21 Polyclonal Antibody?

P21 Polyclonal Antibody is available in the following size(s): 60 µL, 120 µL, 200 µL.

How many pack sizes does P21 Polyclonal Antibody come in?

P21 Polyclonal Antibody is available in 3 different pack sizes.

Is P21 Polyclonal Antibody in stock?

P21 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P21 Polyclonal Antibody?

P21 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for P21 Polyclonal Antibody?

Estimated delivery time for P21 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P21 Polyclonal Antibody?

The safety data sheet for P21 Polyclonal Antibody is available here: https://789.bio/eb/O0e50K.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.